Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution
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چکیده
منابع مشابه
Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution.
A remarkable instability at simple repeated sequences characterizes gastrointestinal cancer of the microsatellite mutator phenotype (MMP). Mutations in the DNA mismatch repair gene family underlie the MMP, a landmark for hereditary nonpolyposis colorectal cancer. These tumors define a distinctive pathway for carcinogenesis because they display a particular spectrum of mutated cancer genes conta...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.190210897